There are often no symptoms in the early stages of myeloma. Once it progresses, some of the more common symptoms are:

• Bone pain

• Bone fractures

• Fatigue

• Weakness

• Recurrent or persistent infections

• Loss of appetite and weight loss

Symptoms related to hypercalcemia or kidney problems may include:

• Increased or decreased urination

• Increased thirst

• Restlessness, which can eventually lead to extreme weakness and fatigue

• Confusion

• Nausea and vomiting