How Is Multiple Myeloma Diagnosed?

Phases of Multiple Myeloma

There are different types of tests performed to diagnose multiple myeloma, including laboratory tests and imaging.

- CBC (complete blood count)
- Chemistry
- Myeloma protein (M-Spike)
- Immunoglobulins (IgA, IgD, IgE, IgG and IgM)
- SPEP (serum protein electrophoresis)
- Serum IFE (immunofixation)
- Serum free light chains
- Beta-2 microglobulin
- UPEP (urine protein electrophoresis)
- Urine IFE (immunofixation) (Bence Jones protein)
- CT (computed tomography scan)
- PET (positron emission tomography) scan
- Skeletal survey
- MRI (magnetic resonance imaging)
- Echocardiogram
- Bone marrow biopsy
- Fine needle aspiration (FNA)
- Cytogenetic testing
- DNA sequencing
- FISH (fluorescence in situ hybridization) testing